Alström syndrome
Share | - Comprehensive articles covering over 1,700 topics. The articles are organized by the disease, condition overview, symptoms, treatment, and prevention.

Drugs search, click the first letter of a drug name:
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9

Terms search, click the first letter of a term name:
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Online medical services

Medical dictionary is a searchable dictionary of medical terms from medicine and related fields. Search for medical terms with our medical dictionary.

Drugs & Medications Search our drug database for comprehensive prescription and patient information on 24,000 drugs online. - The Internet Drug Index for prescription drugs and medications.

PMS blog Premenstrual syndrome (PMS), PMS headache

Blue waffles disease, blog. Blue waffle infection, blue waffle disease pictures.



Disease Reference

Click on the first letter in the disease name:

| 4 | 5 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


Alström syndrome


Alström syndrome is an inherited disease marked by blindness, deafness, diabetes, and obesity.


Alström syndrome is an autosomal recessive inherited disorder, which means that a person must inherit a copy of the defective gene from both parents in order to be affected. It is extremely rare, but is more common in Holland and Sweden than in the United States.

The mutated gene, ALMS1, has been identified, but it is not yet known how this gene causes the disorder.


  • Blindness or severe vision impairment in infancy
  • Symptoms of childhood-onset or type 2 diabetes
  • Obesity
  • Deafness
  • Dark patches of skin (acanthosis nigricans)
  • Growth retardation
  • Impaired heart function (cardiomyopathy), which may lead to heart failure
  • Progressive kidney failure

Occasionally, the following are also associated:

  • Hypothyroidism
  • Liver dysfunction
  • Small penis
  • Gastrointestinal reflux

Exams and Tests

An ophthalmologist will examine the eyes. The patient may have reduced vision.

Tests may be done to check:

  • Triglyceride levels
  • Blood sugar levels (to diagnose hyperglycemia)
  • Thyroid function
  • Hearing
  • Heart function (echocardiogram may be abnormal)


There is no specific treatment for this syndrome. Treatment for specific symptoms may include:

  • Diabetes medication
  • Hearing aids
  • Heart medications
  • Thyroid hormone replacement

Support Groups

Alström Syndrome International --

Outlook (Prognosis)

Permanent blindness, deafness, and type 2 diabetes are likely to develop. Kidney and liver failure may get worse.

Possible Complications

Complications related to diabetes can occur. Impaired heart function, if untreated, can lead to fatigue and shortness of breath. Diabetes and high cholesterol increase the risk of coronary artery disease.

When to Contact a Medical Professional

Call your health care provider if you suspect symptoms of diabetes such as increased thirst and urination. Seek medical attention promptly if you suspect that your infant or child cannot see or hear normally.

Email to a Friend

Your Name:

Friend's Email:

More about Alström syndrome -
   Alström syndrome
Malignant plasmacytoma
African trypanosomiasis
Diarrhea associated with medications
Acute cytomegalovirus (CMV) infection
Asymptomatic HIV infection
Asperger syndrome

Medical dictionary | Natural mosquito repellents | Dust mites pictures | Prescription Drug Information | new 401k rules | Hyperkeratosis pilaris treatment
© Copyright by 2006-2007. All rights reserved