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Hypersplenism

Definition

Hypersplenism is a condition in which the spleen is overactive. It can be caused by tumors, anemia, malaria, tuberculosis, and various connective tissue and inflammatory diseases.

Symptoms include an enlarged spleen that is often accompanied by a low level of one or more types of blood cells. The enlarged spleen can cause stomach pain on the left side, as well as a premature feeling of fullness after eating.

Ferri FF. Ferri's Clinical Advisor 2007: Instant Diagnosis and Treatment. 9th ed. Philadelphia, Pa: Mosby; 2007:443.

Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philladelphia, Pa: Churchill Livingston; 2005:711-12.