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Acidosis - respiratory


Respiratory acidosis is a condition that occurs when the lungs cannot remove all of the carbon dioxideproduced by the body. This creates a disruption in the body's acid-base balance. Bodyfluids become excessively acidic.

Alternative Names

Ventilatory failure; Respiratory failure; Acidosis - respiratory


Respiratory acidosis can result fromlung diseases such as chronic obstructive pulmonary disease (COPD) and severe asthma.

Other conditions that may lead to respiratory acidosis include:

Chronic respiratory acidosis occurs over a long period of time. Thisleads to a stable situation. This is because the kidneys increase chemicals thathelp restore the body's acid-base balance.

Acute respiratory acidosis is a severe condition in whichthe carbon dioxide builds up very quickly.


Symptoms may include shortness of breath, easy fatigue, chronic cough, or wheezing.

When respiratory acidosis becomes severe, confusion, irritability, or lethargy may occur.

Exams and Tests

A chest x-ray or CT scan may be done to diagnose possible lung disease.

Pulmonary function tests may help diagnose lung disease.

Arterial blood gases can tell how bad the respiratory acidosis is, and may detect abnormal oxygen levels.


Treatment is aimed at the underlying lung disease, and may include:

  • Methods to stop smoking (this is extremely important)
  • Bronchodilator drugs to reversesome airway obstruction
  • Oxygen if the blood oxygen level is low
  • Non-invasive positive-pressure ventilation or mechanical ventilation if the respiratory acidosis is severe

Outlook (Prognosis)

How well a patient does depends on thedisease causing the respiratory acidosis.

Possible Complications

  • Respiratoryfailure
  • Poor organ function
  • Shock

When to Contact a Medical Professional

Severe respiratory acidosis is a medical emergency. Seek immediate medical help if you have symptoms of this condition.

Call your health care provider if you have symptoms of lung disease.


Do not smoke. Smoking leads to thedevelopment of many severe lung diseases that can lead to respiratory acidosis.

Losing weight may help prevent obesity hypoventilation syndrome.

Murray J, Nadel J. Textbook of Respiratory Medicine. 3rd ed. Philadelphia, Pa: WB Saunders; 2000: 191-192.

Marx J. Rosen's Emergency Medicine: Concepts and Clinical Practice. 5th ed. St. Louis, Mo: Mosby; 2002:1716-1717.

Ford MD,Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:92.

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